Lrk2 Case Study - 1616 Words

LRRK2 Kinase activity of mutant LRRK2 has been shown to mediate neuronal toxicity and cell death in PD (Smith et al., 2006). The BRAF kinase which is believed to cause a significant proportion of melanoma is similar to the kinase domain of LRRK2, which is known to drive a significant proportion of malignant melanoma (Bishop et al., 2009; Flaherty et al., 2010; Flemming et al., 2010; Paisan Ruiz et al., 2010; Shen J et al., 2004), implying that there could be functional analogies between the activation of the BRAF kinase in melanoma and activation of LRRK2 kinase in PD-associated neurodegeneration (Paisn-Ruiz et al., 2010) DJ-1 DJ-1 was initially identified as an oncogene. It has been reported that mutations in DJ1 causes familial PD. DJ-1†¦show more content†¦It is expressed in melanoma cell lines, and is involved in melanocyte survival by detoxification of the intermediates formed as a result of melanogenesis (Harteneck et al., 2005; Iuga et al., 2007; McNeill MS et al., 2007 ). The heterozygous variant of TRPM7 has been found in some PD patients with dementia and some Guamanian patients (Hermosura et al., 2007). Inhibition of melanin synthesis prevents melanophore cell death in TRPM7 mutants therefore providing a possible clue that can explain the increased risk of PD and ALS in melanoma patients (Bertoni JM et al., 2010) Tumor suppressor gene p53 The tumor suppressor gene p53 plays an important role in human neurodegenerative disorders such as PD. Therefore chemical inhibitors of that activate p53 may be effective in suppressing the neurodegenerative process in PD (Stretch et al., 1991). Loss of p53 function, that has been identified in a variety of human tumor types such as melanoma (Duan W et al, 2002). Therefore it is possible that the risk for PD might be

Marriage in William Shakespeares The Taming of the Shrew...

Marriage in William Shakespeares The Taming of the Shrew At the time Shakespeare wrote The Taming of the Shrew the idealistics and attitudes to not only marriage, but also women were of a whole different nature. A woman would have had to be married to someone with the same social status. The man would indeed have to be rich and offer a safe and secure future. Marriage was based around social standings, money, trade and a way to make an alliance. At the time queen Elizabeth was on the thrown and society saw that unless a man owned†¦show more content†¦Despite all this the Elizabethan woman was intelligent with her life she adapted to the way she was anticipated to behave and let the male figure think he was boss. They often appeared one-way and acted another such as Bianca does in Taming of the Shrew. Today however women have made a stand they are no longer second to anyone but instead an equal with just as much authority right and power as any other man. A few typical traditions however still remain but these are slowly dieing out as women go out to work and dont always stay home to raise a family. Taming of the Shrew is set in Elizabethan times in Italy with traditional views on the womans place in society. The play is fairly controversial, as people believe that it should not be shown as it is out of touch with society. People believe it should not be studied as its basis is extremely sexist. However I feet hat it is relevant as the play is a written piece of history. Indeed it is a piece of fiction but it reflects views of the Elizabethan times and therefore is especially important to society today so that we can move forward for if we forget the past then we dont learn from it. Kates character is a fine example of this, the way she behaved because she stood up for herself and didnt wish to be ridiculed in the streets men didnt find her attractiveShow MoreRelatedMarriage and Relationships in William Shakespeares The Taming of the Shrew2278 Words   |  10 PagesMarriage and Relationships in William Shakespeares The Taming of the Shrew Getting married in modern times is not something which is viewed as necessary. There are many couples that are together, but do not want to marry, because they do not feel they have to. Couples that do, can have a marriage almost anywhere they choose. Couples can marry in houses, shopping centres and even petrol stations. Anywhere you can get a marriage licence and a vicar, is seen as a place fitRead MoreWilliam Shakespeare s Taming Of The Shrew889 Words   |  4 PagesIn many accounts, William Shakespeare’s Taming Of The Shrew, is often criticized for its seemingly misogynistic themes; such as the thought of â€Å"taming† a woman, thus making her completely submissive to her husband. While in the opening of the play, Katharine, ill-tempered but seemingly impenetrable, gets pulverized by Petruchio’s contradicting her words, and also saying disgusting jokes in an intense verbal arguement. In another example, one of the other main characters, Bianca, was bet on by severalRead MoreEssay on The Taming of the Shrew by William Shakespeare1088 Words   |  5 Pages The Taming of the Shrew, written by William Shakespeare, is historical proof that flirting and temptation, relating to the opposite sex, has been around since the earliest of times. Because males and females continue to interact, the complications in this play remain as relevant and humorous today as they did to Elizabethan audiences. This is a very fun play, full of comedy and sexual remarks. Its lasting impression imprints itself into the minds of its readers, for it is an unforgettableRead More Essay on Contrasting Couples in The Taming of the Shrew820 Words   |  4 PagesUse of Contrasting Couples in The Taming of the Shrew      Ã‚   William Shakespeares comedy, The Taming of the Shrew illistrates the difficulty of trying to tame a headstrong, stubborn, and a high-spirited woman so that she will make a docile wife. The one attempting to tame Kate, the shrew, is Petruchio. They contend with each other with tremendous vitality and have a forced relationship. In contrast, there is another romantically linked couple who seemingly possess an ideal relationship. TheseRead MoreThemes in Taming of the Shrew1433 Words   |  6 PagesThe Taming of the Shrew is a comedy written in the early 1590’s by William Shakespeare. This play within a play starts when a powerful lord plays a prank on a poor, drunken man named Christopher Sly. The lord convinces the poor man that he is actually a lord himself and that the troop of actors that have arrived are there to perform a play for him. This play that the troop of actors performs is the story of Petruchio, who wants to marry for money, and Katherina, the shrew. The two actually marryRead MoreWilliam Shakespeares Taming of the Shrew William Shakespeare’s romantic comedy, The Taming of1100 Words   |  5 Pages William Shakespeares Taming of the Shrew William Shakespeare’s romantic comedy, The Taming of the Shrew, is an embodiment of the context in which the text was shaped, the Renaissance. The Renaissance period was a time of progression, primarily in the areas of art, science, humanism, religion and self-awareness. The Renaissance focused on taking elements of the past including religion, art and science and adapting them to make them better. Humanists advocated for the freedom of the individualsRead MoreEssay about Taming of the Shrew: Movie vs. Play807 Words   |  4 Pages William Shakespeares The Taming of the Shrew is an interesting story that demonstrates the patriarchal ideas of how a marriage is suppose to be according to society, what is acceptable of a womans role in a relationship. Its a story that has many things to show for its been remade, and remade, even slightly altered to better relate to the teenage audience. The story is about two sisters Katherine and Bianca. Bianca has a suitor who would like to marry her, Lucentio, but the onlyRead MoreSexism in The Taming of the Shrew by William Shakespeare Essay example1104 Words   |  5 PagesSexism in The Taming of the Shrew by William Shakespeare The Taming Of The Shrew by William Shakespeare is an introduction in the everpresent battle of women to be loving and caring wives, while at the same time holding on to our independence. Its plot is derived from the popular war of the sexes theme in which males and females are pitted against one another for dominance in marriage. The play begins with an induction in which a drunkard, Christopher Sly, is fooled into believing he is a kingRead More Taming of the Shrew: Male Domination Essay1046 Words   |  5 PagesTaming of the Shrew: Male Domination The Taming of the Shrew, by William Shakespeare, deals with marriage. The ideas explored are primarily shown through the characters of Petruchio and Katharina. We are introduced to the trials and tribulations which present themselves in their everyday lives. The characters bring up a traditional concept of male domination. Through the play we see the need for domination through Petruchio, and the methods he uses to dominate. While these ideas of male dominationRead MoreGender Roles During Elizabethan Society1099 Words   |  5 Pages†; Petit, â€Å"A Look at Male Gender Roles in Shakespeare’s Renaissance.).. The men could vote and all actors on stage were men. In general, men had every advantage in that time period (Ram, Pham, Sok, Hamsafar, and Wilhemsen, â€Å"Gender Roles in Elizabethan Society.†; Petit, â€Å"A Look at Male Gender Roles in Shakespeare’s Renaissance.). During the Elizabethan age, marriages were generally viewed as a business relationship than anything else (Folger, 5). Marriages were arranged only to increase the wealth

Measure of Welfare free essay sample

Individual living conditions include non material aspects as health, life expectancy, education and environment. Happiness, as the ultimate goal, does not change much over time as it depends on family, friends, work satisfaction, not much on income. Hence, GDP (a frequently varying and objective measure based on raw formulas and numbers) can definitely not be an accurate measure of a nation welfare (or happiness, by far more subjective and non-changing in nature. ) As discussed in the previous paragraph, there are several layers we need to go through from GDP in order to reach welfare. Each layer will inevitably impose encompassing new considerations in finding the ‘right’ measure for welfare, should the latter be initially based on GDP. To illustrate, the figure below shows a relatively low economic well being in spite of a high GDP per capita for USA, while it depicts a relatively high economic well being in spite of a low GDP per capita for France. In both countries overall happiness and life satisfaction are quite steady over time. 2. From GDP to Welfare Our analysis of the way from GDP to welfare is based on the following illustration. Yet, depreciation does not contribute to welfare in any way, and the replacement of old capital only gets the economy back to the â€Å"starting† position. Such capital consumption (ranging from 10% in UK and more than 20% in Japan) prevents (at least partially) any rise of GDP from benefiting consumers and only replaces physical capital. Similarly, expenditure on crime prevention and security adds significantly to GDP but only restores a safe environment. Medical expenditure as a result of air and noise pollution also adds to GDP as do diet classes, antidepressants and a sizeable list of other items . e. hence comes the notion of the Net Domestic Product as the result of subtracting capital consumption from GDP. Second, GDP measures income produced in a country but not how much of it is received by people in that country. Implicitly speaking, some income may go to foreigners. This is particularly the case in Ireland, which transfers a non negligible 15% of primary income to the rest of the world. On the other side, other countries (Japan and Germany for instance) are net recipients of income from abroad leading to the rise in income of residents outpacing the rise in GDP. Here comes to notion of the Net National Product as the result of subtracting net income receipts from abroad from net domestic product. Third, GDP â€Å"objectively† counts monetary transactions (including estimates for those in the shadow economy) and very often misses many other activities that people â€Å"subjectively† value like caring for children or elderly at home, spending leisure time spent relaxing or with family and friends. GDP does not include the value of clean air and water i. e. ; therefore, any useful measure of well-being would try to capture these items, which are not considered at all by GDP. However, if we take our reasoning the extreme line, this would imply that basic food and clothing also should not be included. This again highlights some of the arbitrariness of the different measures. 2. 2 Some Initiatives towards Welfare Measurement In 1970s a measure of Economic Welfare (MEW) was proposed by James Tobin and William Nordhaus. The principle was to add to GNP the value of household services and leisure, to subtract the cost of capital consumption and â€Å"bring-back† costs such as pollution, and to excludes police services to combat crime and similar. Many later studies used components and weights of different measures, but they were all based on researchers’ own subjective judgment. A very comprehensive and thorough Index of Economic Well-Being comes from the Canadian Centre for the Study of Living Standards. It starts from the flow of private and government consumption (excluding household work). The stock of physical and human capital owned by residents tries to measure the stock of productive resources that can be passed on to the next generation. Inequality is captured through the Gini coefficient and the poverty intensity. Finally, the security component aggregates diverse items such as divorce rates and employment rates (with a negative sign). The overall Index of Economic Well-Being is a weighted average of the four components. The preliminary 2004 results shows that economic well being ranking differ significantly from the ranking for GDP per capita, favoring countries with high income equality and low insecurity. Several countries started publishing or developing national economic well-being measures. So far, there is no international standard for calculating them. The measures differ significantly across countries and may reflect the values and priorities of the researchers who construct them. Over the coming decades we are likely to see more standardization in this area. 4 MBAXIV A – MA 1407 – Business Economics in a Global Market GDP Welfare – The Moroccan Example Still, consumption, wealth, equality and security only capture part of a human’s well-being. Many other elements are relevant as well. Perhaps, the best-known, but rather narrow measure of human living conditions is the United Nations’ annual Human Development Index (HDI): a combination of the levels of life expectancy, education and GDP to measure human development (not necessarily welfare); which makes it a valued contribution but still narrow in scope because of its high correlation with GDP. A more comprehensive measure of human living conditions is the Weighted Index of Social Progress (WISP) calculated by Richard Estes at the University of Pennsylvania and going back to 1970. This index tries to capture many dimensions of wellbeing, covering income, education, health, role of women, environment, social peace, diversity and welfare. In UK, the â€Å"new economics foundation† publishes a Happy Planet Index (HPI): a combination of data on life expectancy, surveys on satisfaction and consumption of natural resources (in an attempt to measure how happy people live without damaging the planet). With such strong focus on the environment, this index favors countries near the equator. Anecdotal evidence suggests that HPI may be a good guide for holiday destinations! Another measure in the UK is the Measure of Domestic Progress (MDP). From consumer expenditure, social costs (inequality, accidents, crime, family breakdown etc. , environmental costs and the loss of natural resources are subtracted. This indicator peaked in the mid-1970s, declined until the mid1980s and has not yet regained any considerable improvement due to rising social and environmental costs. Because the Labor government’s focus on improving the overall quality of life in the UK, this measure has some influence on policy priorities, and reversibly, policy influences measured wellbeing. 2. 3 Happiness and Life Satisfaction The well-being indicators still cannot tell how happy individuals are. Measuring happiness requires a different approach mainly based on surveys. According to the survey of spring 2006, 66% of Danes said they were very satisfied with the life they lead. Only 17% of Germans and just 4% of the Portuguese felt the same way. Over the past 15 years, the average level of life satisfaction has not changed much in spite of the large increase in per capita income. Football events and achievements greatly contributed to satisfaction bumps (france in 1998, Portugal in 2000). Satisfaction of life is influenced by factors other than income, and it is very difficult to boost satisfaction on a sustainable basis mainly because people get used to igher income, consumption and circumstances. For example, by the hedonic treadmill, driving a new car for the first time may make one very happy, but only for a short time. Naturally, humans always aim higher for better living conditions. The satisfaction treadmill can make one feel that it would have been better to have a house in a better or safer neighborhood rather that the just recently completed new house. To make thing even worse, an individual’s satisfaction tends to be influenced by how well others are doing. Driving a big car may make one happy if she is the only person with such a car, but satisfaction with that same car quickly diminishes if friends and neighbors drive similar cars. Also, if one buys a big car, this may depress the happiness of neighbors, so aggregate happiness may not rise. According to Lyubomirsky et al. (2005) a part of happiness appears to be genetically determined (around 50%), another part determined by happiness-relevant activities (40%) and the remainder by circumstances (income, climate, environment, stable democracy etc. ).

Management Theory Jungle free essay sample

The Management Of Theory Jungle It was Harold Kenton who introduced the concept of Management Theory Jungle. Management Theory Jungle was made in an environment where the development of management theory had escalated over a period of two decades. This has resulted to confusion and conflict which many theories have entangled in it. As such, it is seen as a Jungle. Kenton defined the management theory Jungle by identifying and classifying major management theory. Six schools of thoughts were identified. They included the management process, empirical, human behavior, social system, decision theory and the mathematical school. He said that each school had something to offer to management theory but suggested one should not confuse content with tools. For example, the field of human behavior should not be Judged the equivalent of the field of management, nor should a focus on decision making or mathematics be considered as encompassing the entire area of analysis. We will write a custom essay sample on Management Theory Jungle or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Therefore, each of these school would provide insight and methods to aid manager In performing task, hence were tools not school.Problems occurred when there Is a Jungle of confusing and conflicting theories. Semantics Jungle refers to the definitions of certain words or terms In maintenance. There Is a lack of universal recognized definitions In maintenance. Problems In defining management as a body of knowledge which led leads to entanglement as theories in various schools compete to fill the body of knowledge. The misunderstanding of principles through trying to disprove an entire framework when one principle was violated In practice. And lastly, the unwillingness of management theorist to understand each other.